Protein Alignment Scr and NKX6-2

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 206
• Identity: 57/206 - (27%)
• Similarity: 86/206 - (41%)
• Gaps: 44/206 - (21%)

  Fly   220 SPSSVVESVAR---SLNKGVLGGSLAAAAAAAG-------LNNNHSGSGVSGGPGNVNVPMHSPG 274
            :|.:.:.::|.   ||....|.|.....|.|.|       |...|..|.:.|.      |:.:.|
Human    14 APLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGISDILGR------PVGAAG 72

  Fly   275 GG-------DSDSESDSGNEAGSSQNSGNGKKNP-------PQIY--------PWMKRVHLGTS- 316
            ||       .:...|.:|...|.:.....|...|       |.|:        ||......|.:
Human    73 GGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAP 137

  Fly   317 ---TVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMK 378
               .::.:|:.|..|.:::..|...|||.|...:||....|..:|::|.:||.|:|:||||||.|
Human   138 AGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTK 202

  Fly   379 WKKEH--KMAS 387
            |:|.|  :|||
Human   203 WRKRHAVEMAS 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	24/55 (44%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		9/52 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		4/22 (18%)
		Homeodomain	147..205	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		3/4 (75%)