Protein Alignment Scr and nkx2.1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_571851.1
• Gene: nkx2.1 / 81883
• ZFINID: ZDB-GENE-010404-1
• Length: 346
• Species: Danio rerio
• Alignment Length: 353
• Identity: 87/353 - (24%)
• Similarity: 138/353 - (39%)
• Gaps: 80/353 - (22%)

  Fly   206 SPQDLSTRDISPKLSPSSVVESVAR-SLNKGVLGGSLAA----AAAAAGLNNNHSG--------- 256
            ||:..:...:|..|||  :.||..: |:....||..||:    ....|.:..:|.|
Zfish     4 SPKHTTPFSVSDILSP--LEESYKKVSMEGNNLGAPLASYRQPQVTQAAMQQHHMGHNGTVPAAY 66

  Fly   257 ----SGVS-------GGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKR 310
                :|||       ||..|.|:      |..||..:......||:..:.....||...:..:.|
Zfish    67 HMTAAGVSQLSHTAMGGYCNGNL------GNMSDLPAYQDGMRGSTTATSWYGTNPDPRFSTISR 125

  Fly   311 -------VHLGT-STVNANGET------------KRQRTSYTRYQTLELEKEFHFNRYLTRRRRI 355
                   :::|: ||:::..:.            :::|..:::.|..|||:.|...:||:...|.
Zfish   126 FMGSSSGMNMGSMSTLSSLADVGKGMGPLTSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPERE 190

  Fly   356 EIAHALCLTERQIKIWFQNRRMKWKKEHK-MASMNIVPYHMGP----------YGHPYHQFDIHP 409
            .:|..:.||..|:||||||.|.|.|::.| ..|...:....|.          ...|....|..|
Zfish   191 HLASMIHLTPTQVKIWFQNHRYKMKRQAKDKVSQQQMQQDNGSCQQQQQSPRRVAVPVLVKDGKP 255

  Fly   410 SQFAHLSAXDAWHFSGTGXRLNQLYQ---EPYQTAAAASAASGYQSQDGGPIGGGSVGVGGGAGG 471
            .|       .:.|...|| : |..:|   ..:.|..:.| .|.:|||..|. .|.|:.:|..|..
Zfish   256 CQ-------GSSHTPNTGVQ-NHHHQGGNVMFMTNTSLS-MSQHQSQQVGS-AGQSLDLGQHAAS 310

  Fly   472 PGSLAN---GGSNGSGPNSLFASAASSS 496
            |.||..   |.|:.:...|.:.:|...|
Zfish   311 PPSLQTQVPGLSHLNSSGSEYGAALPCS 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	21/55 (38%)
nkx2.1	NP_571851.1	Homeodomain	160..216	CDD:459649	21/55 (38%)