Protein Alignment Scr and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 450
• Identity: 104/450 - (23%)
• Similarity: 150/450 - (33%)
• Gaps: 163/450 - (36%)

  Fly    53 VPSGGTNGGQGSAGAATPGANDYFPAAAAYT------PNLY-------------------PNTPQ 92
            ||.|        ||||.|.|.   |...:::      ||.:                   |..|.
Mouse    65 VPEG--------AGAARPAAP---PRPTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPA 118

  Fly    93 AHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQ 157
            |..|..||.|                    :..:.:.:::...||..|||      |....|..
Mouse   119 ACVAVPAASG--------------------RSPRAELERRALSAATGVAA------AAGAEPTS- 156

  Fly   158 QQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPS 222
                        |.|......:...|.|..:..:.:|:|.:.      :|:| ...:.:|::..:
Mouse   157 ------------AGDSYRADEAEANGYSSGSGRSPTADSEDE------APED-EDEEEAPEVQDA 202

  Fly   223 SVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGP-GNVNVPMHSPGGGDSDSESDSGN 286
            ...|....  ..|.||...:....||.:..:......:.|| ||      |||.....:.:....
Mouse   203 QGTEEPRG--GSGGLGARGSGCPGAAEVEASPVDDTAAPGPRGN------SPGAPGPPATATGAG 259

  Fly   287 EAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTR 351
            .|||:.........|       ||...|:.  :.:|:.:|.||::|..|.:.||.:|...|||:.
Mouse   260 SAGSTPQGAAVTTKP-------KRKRTGSD--SKSGKPRRARTAFTYEQLVALENKFKATRYLSV 315

  Fly   352 RRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLS 416
            ..|:.:|.:|.|||.|:||||||||.||||
Mouse   316 CERLNLALSLSLTETQVKIWFQNRRTKWKK----------------------------------- 345

  Fly   417 AXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGGPIGGGSVGVGGGAGGPGSLA 476
                              |.|   .|..||.:|     ||  ||...|.|.|||.||.|:
Mouse   346 ------------------QNP---GADTSAPTG-----GG--GGPGPGAGPGAGLPGGLS 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	28/55 (51%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		35/188 (19%)
		Homeodomain	289..345	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		22/98 (22%)