Protein Alignment Scr and SHOX

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 64/275 - (23%)
• Similarity: 105/275 - (38%)
• Gaps: 82/275 - (29%)

  Fly   172 DPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVES-VARSLNKG 235
            |..:..|:||||..|...::                           ::...|:|| :|||...|
Human    13 DQKSKDGNGGGGGGGGKKDS---------------------------ITYREVLESGLARSRELG 50

  Fly   236 VLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKN 300
            ....||               ..::.|.|:..|.:..   ...|::.:...|.|:::.:..
Human    51 TSDSSL---------------QDITEGGGHCPVHLFK---DHVDNDKEKLKEFGTARVAEG---- 93

  Fly   301 PPQIYPWMKRVHLGTSTVNANGETK----RQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHAL 361
               ||. .|.......:.:.:|:||    |.||::|..|..|||:.|....|.....|.|::..|
Human    94 ---IYE-CKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRL 154

  Fly   362 CLTERQIKIWFQNRRMKWKKE----HK---------MASMNIVPY-HMGPYGHPYHQFD------ 406
            .|:|.::::||||||.|.:|:    ||         :.:..:.|| :||....|:.|..
Human   155 GLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQLE 219

  Fly   407 ----IHPSQFAHLSA 417
                .||....||:|
Human   220 GVAHAHPHLHPHLAA 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	23/59 (39%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		3/18 (17%)
		Homeodomain	118..174	CDD:459649	22/55 (40%)
		SH3-binding. /evidence=ECO:0000255	242..249
		OAR	272..288	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287