Protein Alignment Scr and En2

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001102684.1
• Gene: En2 / 499964
• RGDID: 1561842
• Length: 323
• Species: Rattus norvegicus
• Alignment Length: 297
• Identity: 89/297 - (29%)
• Similarity: 120/297 - (40%)
• Gaps: 78/297 - (26%)

  Fly   146 QQLAQQQHPQ-------------QQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSN 197
            |.....|||.             :..:::.|...|..|.     |..||.|.:||......|:
  Rat    51 QAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAG-----GARGGEGGAGSTEGGGGAD-- 108

  Fly   198 NNNSQSLASPQDLSTRDI--SPKLSPSSVVESVARSLNKGVLGGSLAAAA---AAAGLNNN---- 253
                   .:.|.|..|:.  :|..:||:              ||.|:.|:   ||.|...:
  Rat   109 -------GAEQILGARESRPNPACAPSA--------------GGPLSGASGDPAADGEGGSKTLS 152

  Fly   254 -HSGSGVSGGPG---NVNVPMHSPGGGDSDSESDSGNEAGSSQNSGN-GKKNPPQIYP-WM---- 308
             |.|:...|.||   :..:.....||||....|||    .|||.|.. |.:  |.::| |:
  Rat   153 LHGGAKKPGDPGGSLDGALKARGLGGGDLSVSSDS----DSSQASATLGAQ--PMLWPAWVYCTR 211

  Fly   309 --KRVHLGTST-----VNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTER 366
              .|...|..:     .|.|.|.||.||::|..|...|:.||..|||||.:||..:|..|.|.|.
  Rat   212 YSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 276

  Fly   367 QIKIWFQNRRMKWKKEHKMASMNIVPYHM---GPYGH 400
            ||||||||:|.|.||  ...:.|.:..|:   |.|.|
  Rat   277 QIKIWFQNKRAKIKK--ATGNKNTLAVHLMAQGLYNH 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	30/55 (55%)
En2	NP_001102684.1	Homeodomain	235..291	CDD:459649	30/55 (55%)
		Engrail_1_C_sig	292..322	CDD:431338	5/20 (25%)