Protein Alignment Scr and NKX3-1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 55/217 - (25%)
• Similarity: 82/217 - (37%)
• Gaps: 67/217 - (30%)

  Fly   211 STRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGG 275
            |.|...|:..|....|           ||     .:.||..|:...:|          |..:|..
Human    48 SQRQRDPEPEPEPEPE-----------GG-----RSRAGAQNDQLSTG----------PRAAPEE 86

  Fly   276 GDSDSESDSGNEAGS----SQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQT 336
            .::.:|::.....||    |:|:.......||               ......||.|.:::..|.
Human    87 AETLAETEPERHLGSYLLDSENTSGALPRLPQ---------------TPKQPQKRSRAAFSHTQV 136

  Fly   337 LELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWK--------------------K 381
            :|||::|...:||:...|..:|..|.|||.|:||||||||.|.|                    |
Human   137 IELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALK 201

  Fly   382 EHKMASMNIVP-YHMGPYGHPY 402
            |...:..::|. |:..|| :||
Human   202 EEAFSRASLVSVYNSYPY-YPY 222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	27/75 (36%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		23/123 (19%)
		Homeodomain	125..181	CDD:459649	26/55 (47%)