Protein Alignment Scr and NKX1-2

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 88/341 - (25%)
• Similarity: 118/341 - (34%)
• Gaps: 123/341 - (36%)

  Fly   170 ANDPV----TPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVAR 230
            :.|||    ||..:|.|....|....:.|    ...:....|:....|:.:.:|.|     .:||
Human    61 SRDPVRQLETPDAAGPGAGQASPLEGSEA----EEEEDAEDPRRPRLRERAARLLP-----GLAR 116

  Fly   231 SLNKGVLGGSLAAAAAAAGLNNNHSGSGV-SGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNS 294
            |.:        |.|.|.|      ||... .||.|.|..|..|||.
Human   117 SPD--------APAGALA------SGEPCEDGGGGPVRSPPGSPGS------------------- 148

  Fly   295 GNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAH 359
                       |..:|..|..:.    .:.:|.||::|..|.:.||.:|...|||:...|:.:|.
Human   149 -----------PRPRRRRLEPNC----AKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLAL 198

  Fly   360 ALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFS 424
            :|.|||.|:||||||||.||||::..|.
Human   199 SLSLTETQVKIWFQNRRTKWKKQNPGAD------------------------------------- 226

  Fly   425 GTGXRLNQLYQEPYQTAAAASAASGYQSQDGGPIGGGSVGVGGGAGGPGSLA---NGGSNGSGPN 486
                              .|:...|...|.|...|||..|.||..|.||:.|   ....:.|..|
Human   227 ------------------GAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPSYSAAN 273

  Fly   487 SLFASAAS---SSQAP 499
            .||.||||   ::.||
Human   274 VLFPSAASFPLTAAAP 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	28/55 (51%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		33/160 (21%)
		Homeodomain	164..220	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		18/97 (19%)