DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scr and PDX1

DIOPT Version :10

Sequence 1:NP_001368995.1 Gene:Scr / 40833 FlyBaseID:FBgn0003339 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_000200.1 Gene:PDX1 / 3651 HGNCID:6107 Length:283 Species:Homo sapiens


Alignment Length:311 Identity:95/311 - (30%)
Similarity:120/311 - (38%) Gaps:99/311 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 SPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPM 270
            ||.|:|..::.|                       ||...|.|.|:::.        |..:.:| 
Human    61 SPPDISPYEVPP-----------------------LADDPAVAHLHHHL--------PAQLALP- 93

  Fly   271 HSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQI-YPWMK--RVH------LGTSTVNANGETKR 326
            |.|.|     ....|.|.|..:     :.|..|: :||||  :.|      .|.:......|.||
Human    94 HPPAG-----PFPEGAEPGVLE-----EPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKR 148

  Fly   327 QRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIV 391
            .||:|||.|.|||||||.||:|::|.||:|:|..|.||||.|||||||||||||||.        
Human   149 TRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEE-------- 205

  Fly   392 PYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGG 456
                                       |.....||. ....: .||.|..|..|... ..:....
Human   206 ---------------------------DKKRGGGTAVGGGGV-AEPEQDCAVTSGEE-LLALPPP 241

  Fly   457 PIGGGSVGVGGGAGGPGSLANGGSNGSGPNSLFASAASSSQAPDCIKYPQE 507
            |..||:|        |.:.......|..|..|.||...||.||   :.|||
Human   242 PPPGGAV--------PPAAPVAAREGRLPPGLSASPQPSSVAP---RRPQE 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ScrNP_001368995.1 Homeodomain 325..381 CDD:459649 40/55 (73%)
PDX1NP_000200.1 Transactivation domain. /evidence=ECO:0000250 13..73 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..71 4/9 (44%)
Antp-type hexapeptide 118..123 2/4 (50%)
Homeodomain 147..203 CDD:459649 40/55 (73%)
Nuclear localization signal. /evidence=ECO:0000250 197..203 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..283 29/129 (22%)

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