DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Scr and PDX1

DIOPT Version :9

Sequence 1:NP_001368995.1 Gene:Scr / 40833 FlyBaseID:FBgn0003339 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_000200.1 Gene:PDX1 / 3651 HGNCID:6107 Length:283 Species:Homo sapiens


Alignment Length:311 Identity:95/311 - (30%)
Similarity:120/311 - (38%) Gaps:99/311 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 SPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPM 270
            ||.|:|..::.|                       ||...|.|.|:::.        |..:.:| 
Human    61 SPPDISPYEVPP-----------------------LADDPAVAHLHHHL--------PAQLALP- 93

  Fly   271 HSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQI-YPWMK--RVH------LGTSTVNANGETKR 326
            |.|.|     ....|.|.|..:     :.|..|: :||||  :.|      .|.:......|.||
Human    94 HPPAG-----PFPEGAEPGVLE-----EPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKR 148

  Fly   327 QRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIV 391
            .||:|||.|.|||||||.||:|::|.||:|:|..|.||||.|||||||||||||||.        
Human   149 TRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEE-------- 205

  Fly   392 PYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGG 456
                                       |.....||......: .||.|..|..|... ..:....
Human   206 ---------------------------DKKRGGGTAVGGGGV-AEPEQDCAVTSGEE-LLALPPP 241

  Fly   457 PIGGGSVGVGGGAGGPGSLANGGSNGSGPNSLFASAASSSQAPDCIKYPQE 507
            |..||:|        |.:.......|..|..|.||...||.||   :.|||
Human   242 PPPGGAV--------PPAAPVAAREGRLPPGLSASPQPSSVAP---RRPQE 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ScrNP_001368995.1 Homeobox 328..381 CDD:395001 38/52 (73%)
PDX1NP_000200.1 Transactivation domain. /evidence=ECO:0000250 13..73 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..71 4/9 (44%)
Antp-type hexapeptide 118..123 2/4 (50%)
Homeobox 149..202 CDD:278475 37/52 (71%)
Nuclear localization signal. /evidence=ECO:0000250 197..203 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..283 29/129 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X14
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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