Protein Alignment Scr and HOXD11

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_067015.2
• Gene: HOXD11 / 3237
• HGNCID: 5134
• Length: 338
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 100/416 - (24%)
• Similarity: 149/416 - (35%)
• Gaps: 154/416 - (37%)

  Fly     3 PDCFAMSSYQFVNSLASCYPQQMNPQQNHPGAGNSS-----------------------AGGSGG 44
            |..|| |...|::..:||       |...|.:.|.:                       .||.||
Human    25 PSDFA-SKPSFLSQPSSC-------QMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGG 81

  Fly    45 GAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDM 109
            |:.|.|.  ..||..||.|.||...|    |:.||||
Human    82 GSAGGGS--SGGGPGGGGGGAGGYAP----YYAAAAA---------------------------- 112

  Fly   110 VDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPV 174
                                      ||||.||.::..:.::..|   ...::.::..| |.:||
Human   113 --------------------------AAAAAAAAEEAAMQRELLP---PAGRRPDVLFK-APEPV 147

  Fly   175 TPGGSGGGGVSGSNNNNNSANSNNN-------------NSQSLASPQDLSTRDISPKLSPSSVVE 226
            ........|.:|:.:|..||...|.             .....|.||.      .|..:|..
Human   148 CAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQP------PPPPAPPQ--- 203

  Fly   227 SVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNE-AGS 290
                             ...||...:..:|:|              .|||...:::..|:| .|:
Human   204 -----------------PEGAADKGDPRTGAG--------------GGGGSPCTKATPGSEPKGA 237

  Fly   291 SQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRI 355
            ::.||...:.||......|     :|:..|...::::|..||:||..|||:||.||.|:.:.:|:
Human   238 AEGSGGDGEGPPGEAGAEK-----SSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRL 297

  Fly   356 EIAHALCLTERQIKIWFQNRRMKWKK 381
            :::..|.||:||:||||||||||.||
Human   298 QLSRMLNLTDRQVKIWFQNRRMKEKK 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	29/55 (53%)
HOXD11	NP_067015.2	DUF3528	26..185	CDD:432284	46/230 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..270		22/135 (16%)
		Homeodomain	267..323	CDD:459649	29/55 (53%)