Protein Alignment Scr and HOXD3

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_008829.3
• Gene: HOXD3 / 3232
• HGNCID: 5137
• Length: 432
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 131/435 - (30%)
• Similarity: 174/435 - (40%)
• Gaps: 103/435 - (23%)

  Fly   143 QQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASP 207
            |.||.|   :.|:...|:     :..|.|    ||..||.|.|.:.:....:..:    |....|
Human     5 QGQQAL---ELPECTMQK-----AAYYEN----PGLFGGYGYSKTTDTYGYSTPH----QPYPPP 53

  Fly   208 QDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVN----- 267
            ...|:.|.....|..| ::|.|........|..|..:....|..|:..|.|.|..|| :|
Human    54 AAASSLDTDYPGSACS-IQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPG-LNSEQQP 116

  Fly   268 ---------VPMHS---PGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNA 320
                     :|..|   ||||....:...|..|.||  |....|   ||:||||.....:...|:
Human   117 PQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSS--SATISK---QIFPWMKESRQNSKQKNS 176

  Fly   321 ---NGE-----------TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIW 371
               .||           :||.||:||..|.:||||||||||||.|.||:|:|:.|.|||||||||
Human   177 CATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIW 241

  Fly   372 FQNRRMKWKKEHKMASMNIVPYHMGP---------YGH----------PYHQFDI-HPSQFAHLS 416
            |||||||:||:.|...:...|....|         .||          |...:|. .|..||. |
Human   242 FQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAK-S 305

  Fly   417 AXDAWHFSGTGXRLNQLYQEPYQTAA-------AASAASGYQSQD--GGP--IGGGSVGVGGGAG 470
            ..:.:..:.....|:....:..:.||       .||...|:.|.:  |.|  :||..|.....|.
Human   306 QPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPAS 370

  Fly   471 GP----GSLANGGSNGSGPNSLFASAASSSQAP------DCIKYP 505
            ||    |.|       |.|:|.....:.::|.|      .|..:|
Human   371 GPVFNLGHL-------SHPSSASVDYSCAAQIPGNHHHGPCDPHP 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	41/55 (75%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..62		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..197		35/135 (26%)
		Antp-type hexapeptide	160..165		3/4 (75%)
		Homeodomain	195..251	CDD:459649	41/55 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..280		4/26 (15%)
		DUF4074	369..430	CDD:463833	12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..432		2/9 (22%)