Protein Alignment Scr and HOXB5

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 122/386 - (31%)
• Similarity: 163/386 - (42%)
• Gaps: 129/386 - (33%)

  Fly     8 MSSYQFVNSLASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGA 72
            |||| ||||.:..||...:.|..:.|:|:|.:|
Human     1 MSSY-FVNSFSGRYPNGPDYQLLNYGSGSSLSG-------------------------------- 32

  Fly    73 NDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAA 137
             .|...||.:|               .:||       .:|..:.     |...:......|   .
Human    33 -SYRDPAAMHT---------------GSYG-------YNYNGMD-----LSVNRSSASSSH---F 66

  Fly   138 AAVAAQQQQQLAQQQHPQQQQQQQQANISCKYAND---PVTPGGSGGGGVSGSNNNNNSANSNNN 199
            .||....:...|    |.|:.:.:||..||..::.   |.|.|.|.|.        ..||:|.::
Human    67 GAVGESSRAFPA----PAQEPRFRQAASSCSLSSPESLPCTNGDSHGA--------KPSASSPSD 119

  Fly   200 NSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPG 264
            .:.|.:|..:.:..|   :.|.||..|..|..|:    ..|||.|.                 |.
Human   120 QATSASSSANFTEID---EASASSEPEEAASQLS----SPSLARAQ-----------------PE 160

  Fly   265 NVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRT 329
            .:.....:|.|                        ..|||:|||:::|:.......:|  ||.||
Human   161 PMATSTAAPEG------------------------QTPQIFPWMRKLHISHDMTGPDG--KRART 199

  Fly   330 SYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNI 390
            :|||||||||||||||||||||||||||||||||:|||||||||||||||||::|:.||::
Human   200 AYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSL 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	52/55 (95%)
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	32/139 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		31/155 (20%)
		Antp-type hexapeptide	176..181		3/4 (75%)
		Homeodomain	195..251	CDD:459649	52/55 (95%)