Protein Alignment Scr and HOXA11

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 88/355 - (24%)
• Similarity: 139/355 - (39%)
• Gaps: 112/355 - (31%)

  Fly    72 ANDYFPAAAAYT--------PNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQ 128
            :|.|.|:...|.        |:..|.||.:            .|....|:...||   :|..::.
Human    11 SNMYLPSCTYYVSGPDFSSLPSFLPQTPSS------------RPMTYSYSSNLPQ---VQPVREV 60

  Fly   129 QQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANIS-CKYANDPV------TPGGSGGGGVSG 186
            ..:::|           .:.|.:.||       :.|:: |..|.:.|      .|..:   ||.|
Human    61 TFREYA-----------IEPATKWHP-------RGNLAHCYSAEELVHRDCLQAPSAA---GVPG 104

  Fly   187 SNNNNNSANSNNNNSQSLAS--------------------------PQDLSTRDISPKLSPSSVV 225
            .....:|||..::.:.:::|                          |::|::.|.     |..
Human   105 DVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDY-----PGD-- 162

  Fly   226 ESVARSLNKG---VLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNE 287
                :|..||   ....|.||||||.|.....|..  |||.|.    .........:.|.....|
Human   163 ----KSAEKGPPAATATSAAAAAAATGAPATSSSD--SGGGGG----CRETAAAAEEKERRRRPE 217

  Fly   288 AGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGE-TKRQRTSYTRYQTLELEKEFHFNRYLTR 351
            :.||..|.:|              |.......::|: |:::|..||:||..|||:||.|:.|:.:
Human   218 SSSSPESSSG--------------HTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINK 268

  Fly   352 RRRIEIAHALCLTERQIKIWFQNRRMKWKK 381
            .:|::::..|.||:||:||||||||||.||
Human   269 EKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	28/55 (51%)
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	26/163 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		28/122 (23%)
		Homeodomain	242..298	CDD:459649	28/55 (51%)