Protein Alignment Scr and HOXA4

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_002132.3
• Gene: HOXA4 / 3201
• HGNCID: 5105
• Length: 320
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 141/456 - (30%)
• Similarity: 172/456 - (37%)
• Gaps: 200/456 - (43%)

  Fly     8 MSSYQFVNS--LASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGV-----------------V 53
            |||: .:||  :...:|    |.:.:  |.:|.:||:.||.||..|.                 :
Human     3 MSSF-LINSNYIEPKFP----PFEEY--AQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQL 60

  Fly    54 PSGGTNGGQGSAGAATPGANDY---------FPAAAAYTPNLYPNTPQAHYANQAAY-----GG- 103
            |..|        |...|.|:.|         :||||     |||    ||.|...||     ||
Human    61 PHAG--------GGREPTASYYAPRTAREPAYPAAA-----LYP----AHGAADTAYPYGYRGGA 108

  Fly   104 -QGNPDMVDYTQLQPQRLLLQQQQQQQQQQHA-HAAAAVAAQQQQQLAQQQHPQQQQQQQQANIS 166
             .|.|.       ||:    |...|.:...|. ||:..:..|....|..:..|....::
Human   109 SPGRPP-------QPE----QPPAQAKGPAHGLHASHVLQPQLPPPLQPRAVPPAAPRR------ 156

  Fly   167 CKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARS 231
            |:.|  |.|||...||...                   |.|  |...|.||
Human   157 CEAA--PATPGVPAGGSAP-------------------ACP--LLLADKSP-------------- 184

  Fly   232 LNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGN 296
                            .||                                             .
Human   185 ----------------LGL---------------------------------------------K 188

  Fly   297 GKKNPPQIYPWMKRVHLGTSTVNAN---GETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIA 358
            ||:  |.:|||||::|:  |.||.:   ||.||.||:|||.|.||||||||||||||||||||||
Human   189 GKE--PVVYPWMKKIHV--SAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIA 249

  Fly   359 HALCLTERQIKIWFQNRRMKWKKEH-----KMASMNIVPYHMGPYG---------HPYHQFDIHP 409
            |.|||:|||:|||||||||||||:|     ||.|.|......||.|         ||:.    ||
Human   250 HTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHP----HP 310

  Fly   410 S 410
            |
Human   311 S 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	48/55 (87%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..77		16/67 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..168		20/85 (24%)
		Antp-type hexapeptide	194..199		3/4 (75%)
		Homeodomain	216..272	CDD:459649	48/55 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..320		13/43 (30%)