DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scr and HOXA4

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_002132.3	Gene:	HOXA4 / 3201	HGNCID:	5105	Length:	320	Species:	Homo sapiens

Alignment Length:	456	Identity:	141/456 - (30%)
Similarity:	172/456 - (37%)	Gaps:	200/456 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSSYQFVNS--LASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGV-----------------V 53
            |||: .:||  :...:|    |.:.:  |.:|.:||:.||.||..|.                 :
Human     3 MSSF-LINSNYIEPKFP----PFEEY--AQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQL 60

  Fly    54 PSGGTNGGQGSAGAATPGANDY---------FPAAAAYTPNLYPNTPQAHYANQAAY-----GG- 103
            |..|        |...|.|:.|         :||||     |||    ||.|...||     ||
Human    61 PHAG--------GGREPTASYYAPRTAREPAYPAAA-----LYP----AHGAADTAYPYGYRGGA 108

  Fly   104 -QGNPDMVDYTQLQPQRLLLQQQQQQQQQQHA-HAAAAVAAQQQQQLAQQQHPQQQQQQQQANIS 166
             .|.|.       ||:    |...|.:...|. ||:..:..|....|..:..|....::
Human   109 SPGRPP-------QPE----QPPAQAKGPAHGLHASHVLQPQLPPPLQPRAVPPAAPRR------ 156

  Fly   167 CKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARS 231
            |:.|  |.|||...||...                   |.|  |...|.||
Human   157 CEAA--PATPGVPAGGSAP-------------------ACP--LLLADKSP-------------- 184

  Fly   232 LNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGN 296
                            .||                                             .
Human   185 ----------------LGL---------------------------------------------K 188

  Fly   297 GKKNPPQIYPWMKRVHLGTSTVNAN---GETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIA 358
            ||:  |.:|||||::|:  |.||.:   ||.||.||:|||.|.||||||||||||||||||||||
Human   189 GKE--PVVYPWMKKIHV--SAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIA 249

  Fly   359 HALCLTERQIKIWFQNRRMKWKKEH-----KMASMNIVPYHMGPYG---------HPYHQFDIHP 409
            |.|||:|||:|||||||||||||:|     ||.|.|......||.|         ||:.    ||
Human   250 HTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHP----HP 310

  Fly   410 S 410
            |
Human   311 S 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	46/52 (88%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..77		16/67 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..168		20/85 (24%)
		Antp-type hexapeptide	194..199		3/4 (75%)
		Homeobox	218..271	CDD:278475	45/52 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..320		13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960