DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scr and HOXA3

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	322	Identity:	94/322 - (29%)
Similarity:	120/322 - (37%)	Gaps:	124/322 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 PMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNP--------PQIYPWMKRVHLGT---STVNANG 322
            |..:|......|.:.....|.::....|..|:|        .||:||||.....|   ::.:::|
Human   112 PAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSG 176

  Fly   323 E-------------TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQN 374
            |             :||.||:||..|.:||||||||||||.|.||:|:|:.|.||||||||||||
Human   177 ESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQN 241

  Fly   375 RRMKWKKEHKMASM-----------------------------NIVPYH-----------MGPYG 399
            ||||:||:.|...|                             |.|||.           .|.||
Human   242 RRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYG 306

  Fly   400 HPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASG----YQSQDGGPIGG 460
            .|...:   |:.....:.                 ..|.:...||.|.:|    |.....|..|.
Human   307 LPPASY---PASLPSCAPP----------------PPPQKRYTAAGAGAGGTPDYDPHAHGLQGN 352

  Fly   461 GSVG----------VGG------------------------GA---GGPGSLANGGSNGSGP 485
            ||.|          |||                        ||   ||.|.|.:|..:|.||
Human   353 GSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	39/52 (75%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		7/34 (21%)
		Antp-type hexapeptide	155..160		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		7/36 (19%)
		Homeobox	195..248	CDD:395001	39/52 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		17/109 (16%)
		DUF4074	378..441	CDD:404218	10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443		7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810