DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scr and HOXA2

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens

Alignment Length:	152	Identity:	60/152 - (39%)
Similarity:	74/152 - (48%)	Gaps:	43/152 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 PGNVNVPMHSPGGGDSDSESDSGNE---AGSSQNSGNGKKNPPQIYPWMKRVHLGTSTV------ 318
            ||  :.|.|..||....|.:.|...   ||:.|        ||: |||||.......|.
Human    61 PG--SHPRHGAGGRPKPSPAGSRGSPVPAGALQ--------PPE-YPWMKEKKAAKKTALLPAAA 114

  Fly   319 -----------------------NANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHA 360
                                   .:.|.::|.||:||..|.||||||||||:||.|.||:|||..
Human   115 AAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAAL 179

  Fly   361 LCLTERQIKIWFQNRRMKWKKE 382
            |.|||||:|:||||||||.|::
Human   180 LDLTERQVKVWFQNRRMKHKRQ 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		11/41 (27%)
		Antp-type hexapeptide	94..99		3/5 (60%)
		Homeobox	147..200	CDD:395001	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810