Protein Alignment Scr and MNX1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005506.3
• Gene: MNX1 / 3110
• HGNCID: 4979
• Length: 401
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 127/571 - (22%)
• Similarity: 166/571 - (29%)
• Gaps: 274/571 - (47%)

  Fly    14 VNSLASCYPQQMNPQQNHPGAGNSS----AGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGAND 74
            :::|.:..|.:....|:.|.|..:|    |.|:|||.||.|.   ||||:|....|.:..|.|
Human     9 IDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGA---SGGTSGSCSPASSEPPAA-- 68

  Fly    75 YFPA----AAAYTPNLYPNTPQAHYA-------------NQAAYGGQGNPDMVDYTQLQPQRLLL 122
              ||    |.:.:|   |....||.|             .....||.|.|
Human    69 --PADRLRAESPSP---PRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGP--------------- 113

  Fly   123 QQQQQQQQQQHAH------AAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGG 181
                    ..|||      ||||.||.....||...||                     .|..||
Human   114 --------HHHAHPGAAAAAAAAAAAAAAGGLALGLHP---------------------GGAQGG 149

  Fly   182 GGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAA 246
            .|:...                                         |......|.|.|.|||||
Human   150 AGLPAQ-----------------------------------------AALYGHPVYGYSAAAAAA 173

  Fly   247 A---------------AGLNNNHSGSGVSGGPGNVNVP---------MHSPGGGDSDSESDSGNE 287
            |               .|.:..|....:..|.|...:.         |..|...|.:|::.|
Human   174 ALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQS--- 235

  Fly   288 AGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRR 352
                                           |..|:.:|.||::|..|.||||.:|..|:||:|.
Human   236 -------------------------------NLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRP 269

  Fly   353 RRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLSA 417
            :|.|:|.:|.|||.|:||||||||||||:..|
Human   270 KRFEVATSLMLTETQVKIWFQNRRMKWKRSKK--------------------------------- 301

  Fly   418 XDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGGPIGGGSVGVGG----------GAGGP 472
                                    |...||...:.|.|   |||..|.||          |...|
Human   302 ------------------------AKEQAAQEAEKQKG---GGGGAGKGGAEEPGAEELLGPPAP 339

  Fly   473 GSLANGG------------------------SNGSGPNSLFASAASSSQAP 499
            |...:|.                        |||:..::..:..:|...:|
Human   340 GDKGSGRRLRDLRDSDPEEDEDEDDEDHFPYSNGASVHAASSDCSSEDDSP 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	33/55 (60%)
MNX1	NP_005506.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..78		19/47 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..120		7/41 (17%)
		Homeodomain	242..298	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..401		21/152 (14%)