DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scr and Hoxb3

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001100512.1	Gene:	Hoxb3 / 303488	RGDID:	1310780	Length:	429	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	132/467 - (28%)
Similarity:	170/467 - (36%)	Gaps:	151/467 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 YPNTPQAHY--------ANQAAYGGQGNPDMVDYTQLQP--QRLLLQQQQQQQQQQHAHAAAAVA 141
            |.||..|.:        :|...|.|...|.....|.|:.  ||.....|.......||.:.....
  Rat     7 YDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNG 71

  Fly   142 AQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLAS 206
            :..:..||.:..|.                .|.:|..|.....:.||:||....|.:...:..||
  Rat    72 SCMRPGLAPEPLPA----------------PPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAS 120

  Fly   207 PQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGS--GVSGGPGNVNVP 269
            .....|:.|.|.:..|       |..:|               |.|:..|:  |..||.|
  Rat   121 SNSTLTKQIFPWMKES-------RQTSK---------------LKNSSPGTAEGCGGGGG----- 158

  Fly   270 MHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRY 334
                |||...|.|..|...|     |.|.|:||                 .:..:||.||:||..
  Rat   159 ----GGGGGGSSSGGGGSGG-----GGGDKSPP-----------------GSAASKRARTAYTSA 197

  Fly   335 QTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK---MASMNIVPYHMG 396
            |.:||||||||||||.|.||:|:|:.|.|:||||||||||||||:||:.|   :||.:..|   .
  Rat   198 QLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGP---S 259

  Fly   397 PYGHPYHQFD--------IH----------PSQFA--HLSAXDAWHFSGTGXRLNQLYQEPYQTA 441
            |.|.|.....        :|          |..|:  |.:|           .|...||.|.:..
  Rat   260 PAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFSKGHQNA----------YALPSNYQPPLKGC 314

  Fly   442 AA-----ASAASGYQSQ----DGGPIG-----GGSVGVGGGA--------GGPGSL--------- 475
            .|     .:.|..|:|.    :||..|     |..|.||||.        .|| ||
  Rat   315 GAPQKYPPTPAPEYESHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGP-SLYGLNHLSHH 378

  Fly   476 --ANGGSNGSGP 485
              .|...||:.|
  Rat   379 PSGNLDYNGAAP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)
Hoxb3	NP_001100512.1	Homeobox	191..244	CDD:395001	38/52 (73%)
Hoxb3	NP_001100512.1	DUF4074	365..427	CDD:404218	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810