DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scr and Hoxd3

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001257967.1	Gene:	Hoxd3 / 288152	RGDID:	1588601	Length:	432	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	129/472 - (27%)
Similarity:	170/472 - (36%)	Gaps:	143/472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AHYANQAAYGGQGNPDMVD----YTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQH 153
            |:|.|...:||.|.....|    .|..||    .............:.::|.:.|....|....|
  Rat    21 AYYENPGLFGGYGYSKATDAYGYSTPHQP----YPPPAAANSLDSDYPSSACSIQSSAPLRAPAH 81

  Fly   154 PQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPK 218
                 :..:.|.||.   .|.|....||||    .|.....||.....|....|         |.
  Rat    82 -----KGAELNGSCM---RPGTGNSQGGGG----GNQPPGLNSEQQPPQPPPPP---------PT 125

  Fly   219 LSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESD 283
            |.|||                                       |.|       ||.|....::.
  Rat   126 LPPSS---------------------------------------PTN-------PGSGVPAKKTK 144

  Fly   284 SGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNA---NGE-----------TKRQRTSYTRY 334
            .|..|.||.::.:     .||:||||.....:...|:   :||           :||.||:||..
  Rat   145 GGPNASSSSSTIS-----KQIFPWMKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSA 204

  Fly   335 QTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGP-- 397
            |.:||||||||||||.|.||:|:|:.|.||||||||||||||||:||:.|...:...|....|
  Rat   205 QLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPER 269

  Fly   398 -------YGH----------PYHQFDI-HPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAA-- 442
                   .||          |...:|. .|..||. |..:.:..:.....|:....:..:.||
  Rat   270 SPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAK-SQPNMYGLAAYTAPLSSCLPQQKRYAAPE 333

  Fly   443 -----AASAASGYQSQD--GGP--IGGGSVGVGGGAGGP----GSLANGGSNGSGPNSLFASAAS 494
                 .||...|:.|.:  |.|  :||..|.....|.||    |.|       |.|:|.....:.
  Rat   334 FEPHPMASNGGGFASANLQGSPVYVGGNFVDSMAPASGPVFNLGHL-------SHPSSASVDYSC 391

  Fly   495 SSQAP------DCIKYP 505
            ::|.|      .|..:|
  Rat   392 AAQIPGNHHHGPCDPHP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	39/52 (75%)
Hoxd3	NP_001257967.1	Homeobox	198..251	CDD:395001	39/52 (75%)
Hoxd3	NP_001257967.1	DUF4074	369..430	CDD:404218	12/47 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810