Protein Alignment Scr and GBX1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 113/421 - (26%)
• Similarity: 159/421 - (37%)
• Gaps: 119/421 - (28%)

  Fly    35 GNSSAGGSGGGAGGSGGVVPSGGTNGGQGSA-------GAATPGANDY----FPAAAAYTP---- 84
            |.|:.||:|||.|            ||.|:|       |...|.:...    :|....|.|
Human     6 GGSAPGGNGGGGG------------GGPGTAFSIDSLIGPPPPRSGHLLYTGYPMFMPYRPLVLP 58

  Fly    85 ----------NLYPNTPQAHYANQ-----AAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHA 134
                      .|.|..|.|.:|.:     .|..||..|.||..|...|............|:..|
Human    59 QALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPQELAA 123

  Fly   135 HAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNN 199
            .||||.|.      |.:.:|:...::.:..:..    |.:.|.
Human   124 AAAAAAAT------AARNNPEPGGRRPEGGLEA----DELLPA---------------------- 156

  Fly   200 NSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPG 264
             .:.:|.|........| :..||...|....|.::..|.   |:|...||......||
Human   157 -REKVAEPPPPPPPHFS-ETFPSLPAEGKVYSSDEEKLE---ASAGDPAGSEQEEEGS------- 209

  Fly   265 NVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTST---------VNA 320
                      ||||:.:....:.||     |.|....|:  |.:|. .|||..         |.|
Human   210 ----------GGDSEDDGFLDSSAG-----GPGALLGPK--PKLKG-SLGTGAEEGAPVTAGVTA 256

  Fly   321 -NGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK 384
             .|:::|:||::|..|.||||||||..:||:...|.:|||||.|:|.|:||||||||.|||   :
Human   257 PGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWK---R 318

  Fly   385 MASMNIVPYHMGPYGHP--YHQFDIHPSQFA 413
            :.:.|:......|..:|  .....:|.::||
Human   319 IKAGNVSSRSGEPVRNPKIVVPIPVHVNRFA 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	34/55 (62%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		12/36 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		38/198 (19%)
		Homeodomain	262..318	CDD:459649	35/58 (60%)