Protein Alignment Scr and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 212
• Identity: 56/212 - (26%)
• Similarity: 84/212 - (39%)
• Gaps: 55/212 - (25%)

  Fly   216 SPKLSPSSVVESVARSL-------NKGVLGGSLAAAAAAAGLNNNHSGSGVS------------G 261
            :|...|||...:||..:       .......:.|||||||.....|...|||            |
Mouse    49 APPSGPSSQAAAVAAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHSAMGSYCNG 113

  Fly   262 GPGNV-NVPMHSPG--GGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANG- 322
            |.||: .:|.::.|  ||           |.::.....|....|: |..:.|....::.||..|
Mouse   114 GLGNMGELPAYTDGMRGG-----------AAAAATGWYGANTDPR-YSSISRFMGPSAGVNVAGM 166

  Fly   323 --------------------ETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQ 367
                                ..:::|..:::.|..|||:.|...:||:...|..:|..:.||..|
Mouse   167 GSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQ 231

  Fly   368 IKIWFQNRRMKWKKEHK 384
            :||||||.|.|.|::.|
Mouse   232 VKIWFQNHRYKMKRQAK 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	21/55 (38%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	21/55 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		1/4 (25%)