Protein Alignment Scr and Tlx2

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_033418.1
• Gene: Tlx2 / 21909
• MGIID: 1350935
• Length: 284
• Species: Mus musculus
• Alignment Length: 250
• Identity: 66/250 - (26%)
• Similarity: 92/250 - (36%)
• Gaps: 102/250 - (40%)

  Fly   173 PVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVL 237
            |..|||..|.|.||.::..::|.|:..:..|..:|
Mouse    28 PEPPGGGLGPGQSGQSHGESAAFSSGFHGASGYAP------------------------------ 62

  Fly   238 GGSLAAAAAAAGLNNNHSGSGVSGGPGNV-NVPMHSP-------------------GGGDSDSES 282
            .||||:..         .||||  |||.| .||.|.|                   ||
Mouse    63 AGSLASLP---------RGSGV--GPGGVIRVPAHRPLPVPPPSGAAPAVPGPSGLGG------- 109

  Fly   283 DSGNEAGSSQNSGNGKKNPPQIYPWM--------KRVHLGTSTVNAN------------GETKRQ 327
             :|..||.:             :|||        .|:....|..:..            .:.|:.
Mouse   110 -AGGLAGLT-------------FPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKP 160

  Fly   328 RTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 382
            |||::|.|.||||:.|...:||....|..:|.||.:|:.|:|.||||||.||:::
Mouse   161 RTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQ 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	28/55 (51%)
Tlx2	NP_033418.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..52		9/23 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..104		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..166		4/25 (16%)
		Homeodomain	158..214	CDD:459649	28/55 (51%)