Protein Alignment Scr and EN1

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 116/435 - (26%)
• Similarity: 153/435 - (35%)
• Gaps: 114/435 - (26%)

  Fly    25 MNPQQNHPGAGNSSAGGSGGGA--GG-SGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNL 86
            |..||..|.:...||.|:...|  || |..:.|....:.|.||.|.:.|.:....|.:....|.|
Human     1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCL 65

  Fly    87 YPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQ 151
               .|.||:           |.:..:....|             .||..|.|     .|.|.|.|
Human    66 ---PPLAHH-----------PHLPPHPPPPP-------------PQHLAAPA-----HQPQPAAQ 98

  Fly   152 QHPQQQ---QQQQQANISCKYANDP-------VTPGGSGGGGVSGSNNNNNSANSN-----NNNS 201
            .|....   ....:.:..||....|       ...||:||||....:....:|..:     ...:
Human    99 LHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRA 163

  Fly   202 QSLAS----------PQDLSTRDISPKLSPSSVVESVARSLN----KGVLGGSLAAAAAAAGLNN 252
            ...||          |.|.|        .|::.....:::.|    ......::|||||||....
Human   164 PGAASLLCAPDANCGPPDGS--------QPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKP 220

  Fly   253 NHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNG------KKNPPQIYP-WM-- 308
            :.:|.|.|||...      || |.......:.||.|.....|.||      ....|.::| |:
Human   221 SDTGGGGSGGGAG------SP-GAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYC 278

  Fly   309 ----KRVHLGTST-----VNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLT 364
                .|...|..|     .....|.||.||::|..|...|:.||..|||:|.:||..:|..|.|.
Human   279 TRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLN 343

  Fly   365 ERQIKIWFQNRRMKWKKE---------HKMASMNIVPYHMGPYGH 400
            |.||||||||:|.|.||.         |.||        .|.|.|
Human   344 ESQIKIWFQNKRAKIKKATGIKNGLALHLMA--------QGLYNH 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	29/55 (53%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		33/130 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		11/38 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		5/23 (22%)
		Homeodomain	305..360	CDD:459649	28/54 (52%)
		Engrail_1_C_sig	361..391	CDD:431338	6/28 (21%)