DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scr and Hoxd3

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	472	Identity:	128/472 - (27%)
Similarity:	170/472 - (36%)	Gaps:	142/472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AHYANQAAYGGQGNPDMVD----YTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQH 153
            |:|.|...:||.|.....|    .|..||    .............:.::|.:.|....|....|
Mouse    21 AYYENPGLFGGYGYSKATDTYGYSTPHQP----YPPPAAANSLDSDYPSSACSIQSSAPLRAPAH 81

  Fly   154 PQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPK 218
                 :..:.|.||.   .|.|....||||    .|.....||.....|....|        .|.
Mouse    82 -----KGAELNGSCM---RPGTGNSQGGGG----GNQPPGLNSEQQPPQPPPPP--------PPT 126

  Fly   219 LSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESD 283
            |.|||                                       |.|       ||.|....::.
Mouse   127 LPPSS---------------------------------------PTN-------PGSGVPAKKTK 145

  Fly   284 SGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNA---NGE-----------TKRQRTSYTRY 334
            .|..|.||.::.:     .||:||||.....:...|:   :||           :||.||:||..
Mouse   146 GGLSASSSSSTIS-----KQIFPWMKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSA 205

  Fly   335 QTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGP-- 397
            |.:||||||||||||.|.||:|:|:.|.||||||||||||||||:||:.|...:...|....|
Mouse   206 QLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPER 270

  Fly   398 -------YGH----------PYHQFDI-HPSQFAHLSAXDAWHFSGTGXRLN------QLYQEP- 437
                   .||          |...:|. .|..||. |. :.:..:... .|:      :.|..|
Mouse   271 SPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAK-SQPNMYGLAAYTAPLSSCLPQQKRYPAPE 334

  Fly   438 YQTAAAASAASGYQSQD--GGP--IGGGSVGVGGGAGGP----GSLANGGSNGSGPNSLFASAAS 494
            ::....||...|:.|.:  |.|  :||..|.......||    |.|       |.|:|.....:.
Mouse   335 FEPHPMASNGGGFASANLQGSPVYVGGNFVDSMAPTSGPVFNLGHL-------SHPSSASVDYSC 392

  Fly   495 SSQAP------DCIKYP 505
            ::|.|      .|..:|
Mouse   393 AAQIPGNHHHGPCDPHP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	39/52 (75%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		45/228 (20%)
		Antp-type hexapeptide	161..166		3/4 (75%)
		Homeobox	199..251	CDD:278475	39/51 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		2/21 (10%)
		DUF4074	370..431	CDD:290032	11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810