DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scr and Hoxb3

DIOPT Version :9

Sequence 1:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus

Alignment Length:	461	Identity:	131/461 - (28%)
Similarity:	170/461 - (36%)	Gaps:	130/461 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 YPNTPQAHY--------ANQAAYGGQGNPDMVDYTQLQP--QRLLLQQQQQQQQQQHAHAAAAVA 141
            |.||..|.:        :|...|.|...|.....|.|:.  ||.....|.......||.:.....
Mouse     7 YDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNG 71

  Fly   142 AQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLAS 206
            :..:..||.:..|.                .|.:|..|.....:.||:||....|.:...:..|.
Mouse    72 SCMRPGLAPEPLPA----------------PPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAG 120

  Fly   207 PQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMH 271
            .....|:.|.|.:..|       |..:|  |..|....|...|      |.|..||.|.
Mouse   121 SNSTLTKQIFPWMKES-------RQTSK--LKNSSPGTAEGCG------GGGGGGGGGG------ 164

  Fly   272 SPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQT 336
              |||       .|:..|.....|.|.|:||                 .:..:||.||:||..|.
Mouse   165 --GGG-------GGSSGGGGGGGGGGDKSPP-----------------GSAASKRARTAYTSAQL 203

  Fly   337 LELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK---MASMNIVPYHMGPY 398
            :||||||||||||.|.||:|:|:.|.|:||||||||||||||:||:.|   :||.:..|   .|.
Mouse   204 VELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGP---SPA 265

  Fly   399 GHPYHQFDIHPSQFAHLSAXDAWHFS---------GTGXR----LNQLYQEPYQTAAA-----AS 445
            |.|.....   |....::| .:...|         |.| :    |...||.|.:...|     .:
Mouse   266 GSPPQPMQ---STAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPT 327

  Fly   446 AASGYQ----SQDGGPIG-----GGSVGVGGGA--------GGP-------------GSLANGGS 480
            .||.|:    ..:||..|     |..|.||||.        .||             |:|...|:
Mouse   328 PASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGA 392

  Fly   481 NGSGPN 486
            ...|||
Mouse   393 APMGPN 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		14/76 (18%)
		Antp-type hexapeptide	129..134		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		24/105 (23%)
		Homeobox	195..248	CDD:365835	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		8/32 (25%)
		DUF4074	369..431	CDD:372548	8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810