Protein Alignment Scr and NKX2-6

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 75/269 - (27%)
• Similarity: 102/269 - (37%)
• Gaps: 55/269 - (20%)

  Fly   239 GSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMH--------------SP-GGGDSDSESDSGNEA 288
            ||....|...|.:....||...|||....:.|.              || |||....|...||..
Human    52 GSEVHNAGGGGGDRKLDGSEPPGGPCEAVLEMDAERMGEPQPGLNAASPLGGGTRVPERGVGNSG 116

  Fly   289 GSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRR 353
            .|.:   .|:...|:.                 .:.::.|..:::.|.|.||:.|...|||:...
Human   117 DSVR---GGRSEQPKA-----------------RQRRKPRVLFSQAQVLALERRFKQQRYLSAPE 161

  Fly   354 RIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFA-HLSA 417
            |..:|.||.||..|:||||||||.|.|::.:..|:.:.       |||     :.|.:.| .:..
Human   162 REHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSLELA-------GHP-----LTPRRVAVPVLV 214

  Fly   418 XDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGGPIGGG-SVGVGGGAGGPG---SLANG 478
            .|.....|.|... ..:..||  :||.|..|.|....|.|.|.| .....|...||.   .||:.
Human   215 RDGKPCLGPGPGA-PAFPSPY--SAAVSPYSCYGGYSGAPYGAGYGTCYAGAPSGPAPHTPLASA 276

  Fly   479 GSNGSGPNS 487
            |....|.|:
Human   277 GFGHGGQNA 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	25/55 (45%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		21/102 (21%)
		Homeodomain	133..189	CDD:459649	25/55 (45%)