Protein Alignment Scr and CDX4

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005184.1
• Gene: CDX4 / 1046
• HGNCID: 1808
• Length: 284
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 111/494 - (22%)
• Similarity: 156/494 - (31%)
• Gaps: 231/494 - (46%)

  Fly    31 HPGAGNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNL-YPNTP--Q 92
            :||...|..|....|.||:||             .|:..|.:|  |.||.|::..: ||:.|  .
Human    14 YPGTLMSPGGDGTAGTGGTGG-------------GGSPMPASN--FAAAPAFSHYMGYPHMPSMD 63

  Fly    93 AHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQ 157
            .|:.:...:|...:|...|::
Human    64 PHWPSLGVWGSPYSPPREDWS-------------------------------------------- 84

  Fly   158 QQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPS 222
                            |.||.|...|....|:             ..:||....:.|.|
Human    85 ----------------VYPGPSSTMGTVPVND-------------VTSSPAAFCSTDYS------ 114

  Fly   223 SVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNE 287
                      |.|.:||..             |||.:.|..|...||            :|:|
Human   115 ----------NLGPVGGGT-------------SGSSLPGQAGGSLVP------------TDAG-- 142

  Fly   288 AGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETK---RQRTSYTRYQTLELEKEFHFNRYL 349
            |..:.:....:.:|   |.||::      ||...|:|:   :.|..||.:|.||||||||.|||:
Human   143 AAKASSPSRSRHSP---YAWMRK------TVQVTGKTRTKEKYRVVYTDHQRLELEKEFHCNRYI 198

  Fly   350 TRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAH 414
            |.:|:.|:|..|.|:|||:||||||||   .||.||....|                   |||.:
Human   199 TIQRKSELAVNLGLSERQVKIWFQNRR---AKERKMIKKKI-------------------SQFEN 241

  Fly   415 LSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQSQDGGPIGGGSVGVGGGAGGPGSLANGG 479
                                                        .||||.....:..||.|
Human   242 --------------------------------------------SGGSVQSDSDSISPGEL---- 258

  Fly   480 SNGSGPNSLFASAASSSQAPDCIK--YPQEFXSQVIIRQ 516
                 ||:.|.:       |..::  .|.|. .|||:.:
Human   259 -----PNTFFTT-------PSAVRGFQPIEI-QQVIVSE 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	32/58 (55%)
CDX4	NP_005184.1	Caudal_act	13..170	CDD:461413	54/295 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..40		10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..155		12/61 (20%)
		Homeodomain	175..230	CDD:459649	34/57 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..259		9/73 (12%)