Protein Alignment Scr and CDX2

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_011533177.1
• Gene: CDX2 / 1045
• HGNCID: 1806
• Length: 321
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 87/321 - (27%)
• Similarity: 119/321 - (37%)
• Gaps: 111/321 - (34%)

  Fly    95 YANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQ 159
            |.:...:.|..|        |.||..:...|.......|..||||.|
Human    14 YPSSVRHSGGLN--------LAPQNFVSPPQYPDYGGYHVAAAAAAA------------------ 52

  Fly   160 QQQANISCKYANDPVTPGGSG------------GGGVSGSNNNNNSANSNNNNSQSLA----SPQ 208
               ||:....:..|..|...|            ||..:.:   |..|:..|..|.:.|    ||.
Human    53 ---ANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAA---NAVAHGLNGGSPAAAMGYSSPA 111

  Fly   209 DLST------RDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVN 267
            |...      ....|..:| |....:.::||.|..|.  ||.|||..|
Human   112 DYHPHHHPHHHPHHPAAAP-SCASGLLQTLNPGPPGP--AATAAAEQL----------------- 156

  Fly   268 VPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKR---VHLGTSTVNANGETKRQRT 329
                ||||                     .::|   :..||::   ..||:..:.:...|.:.||
Human   157 ----SPGG---------------------QRRN---LCEWMRKPAQQSLGSQALTSPSSTVKTRT 193

  Fly   330 S------YTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK 384
            .      ||.:|.||||||||::||:|.||:.|:|..|.|:|||:||||||||.|.:|.:|
Human   194 KDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINK 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	34/61 (56%)
CDX2	XP_011533177.1	Caudal_act	13..179	CDD:461413	49/244 (20%)
		Homeodomain	196..251	CDD:459649	32/54 (59%)