Protein Alignment Scr and nkx2-5

DIOPT Version :10

• Sequence 1: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001116891.1
• Gene: nkx2-5 / 100144646
• XenbaseID: XB-GENE-487966
• Length: 300
• Species: Xenopus tropicalis
• Alignment Length: 302
• Identity: 72/302 - (23%)
• Similarity: 117/302 - (38%)
• Gaps: 79/302 - (26%)

  Fly   197 NNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSG 261
            |....||..||.|:::|     |..||.:.|   :..:....|:...:.....|....|..|.|.
 Frog    18 NLEQHQSGLSPMDITSR-----LENSSCMLS---TFKQEPYPGTPCLSELTEELAQRDSSKGPSP 74

  Fly   262 GPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKR 326
            .||:..|..:.              |..||::..:.||:   |.|..|.:........ :.|..|
 Frog    75 FPGSFFVKNYL--------------EMDSSKDPKDDKKD---ICPLQKTLEHDKREAE-DPERPR 121

  Fly   327 Q------RTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKM 385
            |      |..:::.|..|||:.|...:||:...|..:|:.|.||..|:||||||||.|.|::.:.
 Frog   122 QRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQD 186

  Fly   386 ASMNIV----PYHM----------------GPYGHPY------HQFDIHP--SQFAHLSAXDAWH 422
            .::.:|    |..:                .||..||      :.::.:|  |.:::.:. .:::
 Frog   187 QTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAYSNYSNPACSGSYN 251

  Fly   423 FS----------GTGXR--------LNQLYQEPYQTAAAASA 446
            .|          ..| .        ||.: |.|.|.|:..||
 Frog   252 CSYSSMPSMQPTSAGNNFMNFSVGDLNTV-QTPIQQASGVSA 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	25/61 (41%)
nkx2-5	NP_001116891.1	Homeodomain	132..182	CDD:459649	22/49 (45%)
		COG5576	<133..235	CDD:227863	29/101 (29%)