DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and LHX2

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	210	Identity:	45/210 - (21%)
Similarity:	80/210 - (38%)	Gaps:	55/210 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 LGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQI 378
            |..|:||.:..|.|..              ||..:|                .||.||::..||:
Human   244 LSCNENDAEHLDRDQP--------------YPSSQK----------------TKRMRTSFKHHQL 278

  Fly   379 LELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDA--- 440
            ..::..|..|.....:...::|....|::|.:::||||.|.|::: |.|........|:.||
Human   279 RTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRR-NLLRQENTGVDKSTDAALQ 342

  Fly   441 NGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIGDVSSSL-----G 500
            .|.|:..|.:.:..:.|                ...||.....:.|.:|.::..|.:|:     |
Human   343 TGTPSGPASELSNASLS----------------PSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEG 391

  Fly   501 NPPYIPAAPETTSSY 515
            :.|:.|:....|:.:
Human   392 HEPHSPSQTTLTNLF 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	15/51 (29%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	38/177 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		8/49 (16%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		10/61 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000