DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and LHX4

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	214	Identity:	46/214 - (21%)
Similarity:	83/214 - (38%)	Gaps:	46/214 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 DEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTR 393
            ||..:.|  ||..:    .|:.:.....|...:.|  .||.||..|..|:..|:..:..:....|
Human   128 DEFYLME--DGRLV----CKEDYETAKQNDDSEAG--AKRPRTTITAKQLETLKNAYKNSPKPAR 184

  Fly   394 RRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASK 458
            ..|.:::....|..|.:::||||||.|.|:..|            ||..:......|..||:...
Human   185 HVREQLSSETGLDMRVVQVWFQNRRAKEKRLKK------------DAGRHRWGQFYKSVKRSRGS 237

  Fly   459 KQQQAQQQQQ-----SQQQQTQQTPVMNECIRSDSL-ESIGDVSSSL------------------ 499
            .:|:.:...:     ..:...::..:::|...::.: .::|||:...
Human   238 SKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDL 302

  Fly   500 --GNPPYIPAAPETTSSYP 516
              |:|..||.:|.:.||.|
Human   303 RDGSPYGIPQSPSSISSLP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	16/51 (31%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	6/21 (29%)
		Homeobox	160..213	CDD:306543	16/52 (31%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		5/19 (26%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211		7/11 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910