DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and NKX6-2

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_796374.2	Gene:	NKX6-2 / 84504	HGNCID:	19321	Length:	277	Species:	Homo sapiens

Alignment Length:	98	Identity:	34/98 - (34%)
Similarity:	52/98 - (53%)	Gaps:	3/98 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 PWMKKIHVAG--VANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSE 407
            || :...:||  .|.|......:.|..|..::..||..|||.|...:||....|..:|::|.::|
Human   126 PW-RDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTE 189

  Fly   408 RQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDA 440
            .|:|:||||||.||:|.:.:......:|:..||
Human   190 SQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDA 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	22/51 (43%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250\|UniProtKB:D3Z4R4	89..142		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..155		6/22 (27%)
		Homeobox	151..204	CDD:306543	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..250		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910