DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and ALX1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_008913.2	Gene:	ALX1 / 8092	HGNCID:	1494	Length:	326	Species:	Homo sapiens

Alignment Length:	201	Identity:	52/201 - (25%)
Similarity:	82/201 - (40%)	Gaps:	48/201 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 KRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTK 431
            :|.||.:|..|:.||||.|....|.....|.::|....|:|.::::||||||.||:
Human   133 RRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWR--------- 188

  Fly   432 NVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQ-QQQQSQQQQTQQTPVMNECIRSDSLESI--- 492
                                      |:::..| ||.:|....|....|:.   |:||...|
Human   189 --------------------------KRERYGQIQQAKSHFAATYDISVLP---RTDSYPQIQNN 224

  Fly   493 ---GDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNNNNNNSNLNNNNNNNQM- 553
               |:.|.  |:.......|..|||......|....:::.:|.:|:.|..::..|||...::.:
Human   225 LWAGNASG--GSVVTSCMLPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLT 287

  Fly   554 GHTNLH 559
            |.||.|
Human   288 GATNGH 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	21/51 (41%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	22/88 (25%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		28/107 (26%)
		OAR	302..320	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910