DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and PITX1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_002644.4	Gene:	PITX1 / 5307	HGNCID:	9004	Length:	314	Species:	Homo sapiens

Alignment Length:	312	Identity:	74/312 - (23%)
Similarity:	118/312 - (37%)	Gaps:	91/312 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GLKLEKRIEEAVPAGQQLQELG----------MRLRCDDMGSENDD--MSEEDRLMLDRSPDELG 315
            |:.||:..|...|......::|          .|...::..||:.|  :.|::|....:.|::.|
Human     7 GMSLERLPEGLRPPPPPPHDMGPAFHLARPADPREPLENSASESSDTELPEKERGGEPKGPEDSG 71

  Fly   316 SNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILE 380
            :...    |...:|:              |..||               :.:||||.:|..|:.|
Human    72 AGGT----GCGGADD--------------PAKKK---------------KQRRQRTHFTSQQLQE 103

  Fly   381 LEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVD-ANGNP 444
            ||..|..|||.....|.|||....|:|.::::||:|||.||:        |..|.:.:| ..|..
Human   104 LEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWR--------KRERNQQLDLCKGGY 160

  Fly   445 TP-------------VAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRS--DSLESIGD 494
            .|             .|.......|:|....|....:|.......:|:.::.:.|  .|:.|: .
Human   161 VPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSM-T 224

  Fly   495 VSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNNNNNNSNLNN 546
            :.||:| |..:|..|                 |:|.   ||.||...|:||:
Human   225 MPSSMG-PGAVPGMP-----------------NSGL---NNINNLTGSSLNS 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	23/51 (45%)
PITX1	NP_002644.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		25/128 (20%)
		COG5576	36..>146	CDD:227863	39/150 (26%)
		Homeobox	93..146	CDD:395001	24/60 (40%)
		Interaction with PIT-1. /evidence=ECO:0000250	147..279		28/131 (21%)
		OAR	276..293	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	280..293
		Nuclear localization signal. /evidence=ECO:0000255	286..290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910