DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and PRRX2

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_057391.1	Gene:	PRRX2 / 51450	HGNCID:	21338	Length:	253	Species:	Homo sapiens

Alignment Length:	221	Identity:	52/221 - (23%)
Similarity:	76/221 - (34%)	Gaps:	66/221 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 PPTNTALGLQELGLKLEKR--------IEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLML 307
            ||...|||..:.. :..|.        :||...||:.....|.|              .|.|...
Human    20 PPPPPALGPGDCA-QARKNFSVSHLLDLEEVAAAGRLAARPGAR--------------AEAREGA 69

  Fly   308 DRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPG--------M 364
            .|.|.           |.|...|   |...|||                  ...||        .
Human    70 AREPS-----------GGSSGSE---AAPQDGE------------------CPSPGRGSAAKRKK 102

  Fly   365 EPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNK--- 426
            :.:|.||.:...|:..||:.|....|.....|.|:|..:.|||.::::||||||.|::::.:
Human   103 KQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAML 167

  Fly   427 LPNTKNVRKKTVDANGNPTPVAKKPT 452
            ...:.::.|..........|||.:||
Human   168 ASRSASLLKSYSQEAAIEQPVAPRPT 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	20/51 (39%)
PRRX2	NP_057391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/13 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..113		18/103 (17%)
		Homeobox	109..161	CDD:395001	19/51 (37%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	230..243
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910