DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and MSX2

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_002440.2	Gene:	MSX2 / 4488	HGNCID:	7392	Length:	267	Species:	Homo sapiens

Alignment Length:	148	Identity:	44/148 - (29%)
Similarity:	71/148 - (47%)	Gaps:	36/148 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 SDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQP---GMEP-----------KRQRTAYTRH 376
            |::.||..|           ||::       .|.|.|   .|.|           ::.||.:|..
Human   106 SENSEDGAA-----------WMQE-------PGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTS 152

  Fly   377 QILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKK--DNKLPNTKNVRKKTVD 439
            |:|.||::|...:||:...|.|.:.:|.|:|.|:||||||||.|.|:  :.:|...|...|..:.
Human   153 QLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLP 217

  Fly   440 ANGN-PTPVAKKPTKRAA 456
            ::.: |.|:: .|.:.|:
Human   218 SSFSLPFPIS-SPLQAAS 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	25/51 (49%)
MSX2	NP_002440.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..147		6/37 (16%)
		Homeobox	145..199	CDD:365835	25/53 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910