DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and zfh1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	85/500 - (17%)
Similarity:	144/500 - (28%)	Gaps:	190/500 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 AHHHNPHSHSHSH----------THSLPHHHSNSAISGHHQASA--GGYSSNYANATPPSHPHS- 142
            |...:|..|....          .|.:.:..|::.:.|...|.|  ..:..||.||...:.||:
  Fly   434 ASRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNF 498

  Fly   143 -------HPHAHPHQSLGYYVHHAPEFISAGA------------------------------VHS 170
                   .|..||     |.:....:..:||.                              :..
  Fly   499 MAAAAGLDPRVHP-----YSIQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEE 558

  Fly   171 DPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSP 235
            ..|....|.......:.                                    .:....|:..||
  Fly   559 PETKEMAPTPEATEAAT------------------------------------PIKREESREASP 587

  Fly   236 HSQMMDLPLQCSSTE-PPTNTALGLQELGLKLEKR---IEEAVPAGQQLQELGMRLRCDDMGSEN 296
            ..:......|....| .|.|.|          |:|   :||..|.     |....|||.....:.
  Fly   588 DPESYRSSSQAIKQEQEPLNVA----------EERQTPVEEHAPV-----EHAADLRCSRCSKQF 637

  Fly   297 D---DMSEEDRLMLDRSPDEL---------------GSNDNDDDLGDSDSDEDLMAETTDGERII 343
            :   ::.:.::::.....:||               .:::.|::..:.|.:|:...|:  |||.:
  Fly   638 NHPTELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQES--GERKV 700

  Fly   344 YPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSER 408
                                    |.|||....|..:|::.:..|...:|.....||..|.|..|
  Fly   701 ------------------------RVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPR 741

  Fly   409 QIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANG--NPTPVAKKPTKRAASKKQQQAQQQQQSQQ 471
            .:::||||.|.:.:|.....|.:        |.|  .|.|:                    .||.
  Fly   742 VVQVWFQNNRSRERKMQSFQNNQ--------AAGAAPPMPI--------------------DSQA 778

  Fly   472 QQTQQTPVMNECIRSDSLESIGDVSSSLGNPPYIPAAPETTSSYP 516
            ..|::...::..::.|.|     ...|..:|||| |.|...:..|
  Fly   779 SLTREDQPLDLSVKRDPL-----TPKSESSPPYI-APPSGEALNP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	17/51 (33%)
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368
		zf-C2H2	355..377	CDD:278523
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	369..391	CDD:290200
		Homeobox	703..755	CDD:278475	17/51 (33%)
		C2H2 Zn finger	969..989	CDD:275368
		zf-H2C2_2	981..1006	CDD:290200
		COG5048	992..>1045	CDD:227381
		C2H2 Zn finger	997..1017	CDD:275368
		zf-H2C2_2	1009..1034	CDD:290200
		C2H2 Zn finger	1025..1042	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000