DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and unc-4

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	108/515 - (20%)
Similarity:	168/515 - (32%)	Gaps:	146/515 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 AHHHNPHSH------------SHSHTHSLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSH 143
            :|::|.::|            |.:.::|:|:.|..:|  |.|  ..||..|:..:.:........
  Fly    28 SHNNNNNNHSPKEIPEETGRSSSTSSNSIPNAHRTNA--GQH--LLGGSPSSACSTSVSGCGMPS 88

  Fly   144 PHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGP--AANVPNTSNGGGGGGSGAVLG-----GG 201
            ...||..:|..|.  |...::...|...|   :||  ...||     |..|.:|..||     ..
  Fly    89 EGLHPTAALQLYA--AAAQLAPNGVRVPP---WGPFLQFGVP-----GVFGPNGPFLGRPRFDAA 143

  Fly   202 AVGGSANGYYGGYGGGYGTA-NGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLK 265
            :.||..|............| |.|....:..|.|..:.......|.::.....:|...:|. .|.
  Fly   144 SAGGHPNSAAAAAAATQMAAVNASNAFANLTGLSAAALRNVSAAQTTAVAAVASTVATIQH-RLM 207

  Fly   266 LEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDE 330
            :..| :...|||                                 |...|||::....||.|.|.
  Fly   208 IGNR-QSLPPAG---------------------------------PPSEGSNEDGGFPGDGDDDS 238

  Fly   331 DLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRR 395
            .                               ..:.:|.||.:...|:.|||:.|..:.|.....
  Fly   239 S-------------------------------AAKRRRSRTNFNSWQLEELERAFSASHYPDIFM 272

  Fly   396 RIEIAHTLVLSERQIKIWFQNRRMKWKK---DNKLPN--TKNVRKKTVDANGNPTPVAKKPTKRA 455
            |..:|..|.|.|.::.:||||||.|.:|   ..|.|.  ..|.:.:|  .:|.|.|..:...|..
  Fly   273 REALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGPGRPAHNAQPQT--CSGEPIPPNELKAKER 335

  Fly   456 ASKKQQQAQQ-QQQSQQQQTQQTPVMNECIR-------------SDS-LESIGDVSSSLGNPPYI 505
            |.::::.|:. .:|:::.|.:...|..|.::             ||| ||..|.....:|.
  Fly   336 ARRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKANGTFSDSDLEDDGIQIDVVGG---- 396

  Fly   506 PAAPETTSSYPG-----SQQHLSNNNNNGSGNNNNNNNNNNSNLNNNNNNNQMGHTNLHG 560
                 |.|...|     |...|......|.|.........:|:|          |..|.|
  Fly   397 -----TDSDDEGDSDAVSPVRLGGGGGGGGGTGGGGGGGASSSL----------HCGLDG 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	20/51 (39%)
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	20/52 (38%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910