DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and HOXC6

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_004494.1	Gene:	HOXC6 / 3223	HGNCID:	5128	Length:	235	Species:	Homo sapiens

Alignment Length:	178	Identity:	76/178 - (42%)
Similarity:	104/178 - (58%)	Gaps:	17/178 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 DMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERI-IYPWMKKIHV-A 353
            |.|| |....|:|.|...|. :.||.|.......|..|::...|.......| |||||::::. :
Human    71 DYGS-NSFYQEKDMLSNCRQ-NTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHS 133

  Fly   354 GVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRR 418
            ||..|:     :.:|.|..|:|:|.||||||||:|||||||||||||:.|.|:||||||||||||
Human   134 GVGYGA-----DRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRR 193

  Fly   419 MKWKKDNKLPNTKNVRKKTVDANGNPT--PVAKKPTKRAASKKQQQAQ 464
            |||||::.|.:|.:      ...|..|  .:..|..||..:::::|.:
Human   194 MKWKKESNLTSTLS------GGGGGATADSLGGKEEKREETEEEKQKE 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	41/51 (80%)
HOXC6	NP_004494.1	Antp-type hexapeptide	122..127		4/4 (100%)
		Homeobox	145..198	CDD:395001	42/52 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..235		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810