DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and HOXB6

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_011523029.1	Gene:	HOXB6 / 3216	HGNCID:	5117	Length:	288	Species:	Homo sapiens

Alignment Length:	396	Identity:	110/396 - (27%)
Similarity:	153/396 - (38%)	Gaps:	146/396 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SLPHHHSNSAISGHHQ----ASAG----GYS----SNY--ANATPPSHPHSHPHAHPHQSLGYYV 156
            |||   .|:.:|.|.:    .|.|    |::    |:|  .....|:. ...|.|.|.....|:|
Human    10 SLP---ENAQVSRHSRRREPRSTGRQFCGFNAARRSDYKTQQIINPAE-QQRPRAPPLPMSSYFV 70

  Fly   157 HHA-PEFISAG------------AVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSAN 208
            :.. |..:::|            :.::||...| ||...|..              |...|.:.:
Human    71 NSTFPVTLASGQESFLGQLPLYSSGYADPLRHY-PAPYGPGP--------------GQDKGFATS 120

  Fly   209 GYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEA 273
            .||...|||||.|            :|          |              :.|         .
Human   121 SYYPPAGGGYGRA------------AP----------C--------------DYG---------P 140

  Fly   274 VPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTD 338
            .||..:.:|....|...|   |......|.|                  ..|...|:.:..||.:
Human   141 APAFYREKESACALSGAD---EQPPFHPEPR------------------KSDCAQDKSVFGETEE 184

  Fly   339 GE--RIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAH 401
            .:  ..:||||::::...  :.|:.|  ..:|.|..|||:|.|||||||||||||||||||||||
Human   185 QKCSTPVYPWMQRMNSCN--SSSFGP--SGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAH 245

  Fly   402 TLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQ 466
            .|.|:|||||||||||||||||::||                            .|..|..|:::
Human   246 ALCLTERQIKIWFQNRRMKWKKESKL----------------------------LSASQLSAEEE 282

  Fly   467 QQSQQQ 472
            ::.|.:
Human   283 EEKQAE 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	44/51 (86%)
HOXB6	XP_011523029.1	Homeobox	214..266	CDD:278475	44/51 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810