DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and HOXB4

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_076920.1	Gene:	HOXB4 / 3214	HGNCID:	5115	Length:	251	Species:	Homo sapiens

Alignment Length:	166	Identity:	89/166 - (53%)
Similarity:	101/166 - (60%)	Gaps:	27/166 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDE 330
            |..|.....|||..|.|.|.  ||:.:.|               ||.......|  .|..|.|
Human    89 LSPRAPAPPPAGALLPEPGQ--RCEAVSS---------------SPPPPPCAQN--PLHPSPS-- 132

  Fly   331 DLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRR 395
                .:...|.::||||:|:||:.| |.:|..| ||||.||||||.|:|||||||||||||||||
Human   133 ----HSACKEPVVYPWMRKVHVSTV-NPNYAGG-EPKRSRTAYTRQQVLELEKEFHYNRYLTRRR 191

  Fly   396 RIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTK 431
            |:||||.|.||||||||||||||||||||:||||||
Human   192 RVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTK 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	46/51 (90%)
HOXB4	NP_076920.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		17/69 (25%)
		Antp-type hexapeptide	141..146		3/4 (75%)
		Homeobox	165..218	CDD:278475	46/52 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..251		7/8 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6194
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45771
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4536
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.940