DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and HOXB1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_002135.2	Gene:	HOXB1 / 3211	HGNCID:	5111	Length:	301	Species:	Homo sapiens

Alignment Length:	381	Identity:	100/381 - (26%)
Similarity:	140/381 - (36%)	Gaps:	109/381 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DYMAHHHNPHSHS-HSHTHSLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHS-HPHAHPHQ 150
            :|...:..|.::| ||...|.|   .:||.:....||.|.|....  ::|....:| :|...|..
Human    11 EYPLCNRGPSAYSAHSAPTSFP---PSSAQAVDSYASEGRYGGGL--SSPAFQQNSGYPAQQPPS 70

  Fly   151 SLGY-YVHHAPEFISAGAVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGY 214
            :||. :...||    :|...:..:..|||:...|...:.|.||.......|..:||.::||  |.
Human    71 TLGVPFPSSAP----SGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPSSYGAQLGGLSDGY--GA 129

  Fly   215 GGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQ 279
            ||.              |..|:              ||.:...|        .::.....||..
Human   130 GGA--------------GPGPY--------------PPQHPPYG--------NEQTASFAPAYA- 157

  Fly   280 LQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIY 344
                                                      ||...|.:....:|........:
Human   158 ------------------------------------------DLLSEDKETPCPSEPNTPTARTF 180

  Fly   345 PWMK-KIHVAGVANGSYQPGM-EPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSE 407
            .||| |.:....|..| :||: .|...||.:|..|:.|||||||:|:||:|.||:|||.||.|:|
Human   181 DWMKVKRNPPKTAKVS-EPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNE 244

  Fly   408 RQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQA 463
            .|:||||||||||.||..:             ..|...|......|.||.....|:
Human   245 TQVKIWFQNRRMKQKKRER-------------EEGRVPPAPPGCPKEAAGDASDQS 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	35/51 (69%)
HOXB1	NP_002135.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..77		17/61 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..149		9/59 (15%)
		Antp-type hexapeptide	179..184		1/4 (25%)
		Homeobox	207..259	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..301		12/47 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810