DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dfd and HOXA10

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens

Alignment Length:	454	Identity:	110/454 - (24%)
Similarity:	154/454 - (33%)	Gaps:	147/454 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SGAVGGGAGVGSVGGGGAGGMTGHPHSMHP--ADMVSDYMAHHHNPHS-HSHSHTHSLPHHHSNS 114
            ||....|.|.|..||||.||...|.....|  ||:          |:. .|.....:|....:.:
Human    37 SGRGEAGGGGGGAGGGGGGGYYAHGGVYLPPAADL----------PYGLQSCGLFPTLGGKRNEA 91

  Fly   115 AISGHHQASAG------GYSSN----YANAT----------PPSHPHSHPHAHPH---------- 149
            |..|......|      ||..:    :.:|.          ||..|...|...|.
Human    92 ASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATS 156

  Fly   150 --------QSLGYYVHHA----------------------PEFISAGAVHSDPTNGYGPAANVPN 184
                    :...|.::.:                      |:..:.|.....|..||...:....
Human   157 CSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYG 221

  Fly   185 TSNGGGGGGSGA-VLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSS 248
            |:.|.|.||.|| .||.|.......|  .|:......|:||..:...:      :.:|.|
Human   222 TAKGYGSGGGGAQQLGAGPFPAQPPG--RGFDLPPALASGSADAARKE------RALDSP----- 273

  Fly   249 TEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDE 313
              ||...|.|               ...|.|             |.|....|......|..:|.|
Human   274 --PPPTLACG---------------SGGGSQ-------------GDEEAHASSSAAEELSPAPSE 308

  Fly   314 LG-SNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQ 377
            .. ::...|.||:|..:                        ..||  :......:::|..||:||
Human   309 SSKASPEKDSLGNSKGE------------------------NAAN--WLTAKSGRKKRCPYTKHQ 347

  Fly   378 ILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDAN 441
            .|||||||.:|.||||.||:||:.::.|::||:||||||||||.||.|:   ...:|:.|.:.|
Human   348 TLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNR---ENRIRELTANFN 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	34/51 (67%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158		11/68 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		35/186 (19%)
		Homeobox	339..392	CDD:278475	34/52 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910