Protein Alignment Dfd and HOXA4

DIOPT Version :9

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_002132.3
• Gene: HOXA4 / 3201
• HGNCID: 5105
• Length: 320
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 153/488 - (31%)
• Similarity: 184/488 - (37%)
• Gaps: 183/488 - (37%)

  Fly     1 MSSFLMGYPHAPHHVQSPMSMGNGLDPKFPPLADDYHHYNGHYSMTASTGHMSGAVGGGAGVGSV 65
            |||||:.              .|.::|||||. ::|..::|           ||...||.
Human     3 MSSFLIN--------------SNYIEPKFPPF-EEYAQHSG-----------SGGADGGP----- 36

  Fly    66 GGGGAGGMTGHPHSMHPADMVSDYMAHHHNPHSHSHSHTHSLPHHHSNSAISGHHQASAGGYSSN 130
             |||.|      :...||.           |..|.......|||      ..|..:.:|..|:..
Human    37 -GGGPG------YQQPPAP-----------PTQHLPLQQPQLPH------AGGGREPTASYYAPR 77

  Fly   131 YANATPPSHPHS--HPHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGPAANVPNTSNGGGGGG 193
              .|..|::|.:  :| ||......|     |.....||....|.....|.|...
Human    78 --TAREPAYPAAALYP-AHGAADTAY-----PYGYRGGASPGRPPQPEQPPAQAK---------- 124

  Fly   194 SGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDL--PLQCSSTEPPTNTA 256
                       |.|:|.                      |:.|.....|  |||..:..|..
Human   125 -----------GPAHGL----------------------HASHVLQPQLPPPLQPRAVPPAA--- 153

  Fly   257 LGLQELGLKLEKRIEEA-----VPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGS 316
                      .:|.|.|     ||||      |....|             ..|:.|:||  ||.
Human   154 ----------PRRCEAAPATPGVPAG------GSAPAC-------------PLLLADKSP--LGL 187

  Fly   317 NDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQILEL 381
            ...                    |.::|||||||||:.| |.||..| ||||.||||||.|:|||
Human   188 KGK--------------------EPVVYPWMKKIHVSAV-NPSYNGG-EPKRSRTAYTRQQVLEL 230

  Fly   382 EKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTP 446
            |||||:||||||||||||||||.|||||:||||||||||||||:||||||.....:..|:..|
Human   231 EKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGP-- 293

  Fly   447 VAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPV 479
                     ..|.|.|:..........| .|||
Human   294 ---------PGKAQTQSPHLHPHPHPST-STPV 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	46/51 (90%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..77		21/98 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..168		20/122 (16%)
		Antp-type hexapeptide	194..199		3/4 (75%)
		Homeobox	218..271	CDD:278475	46/52 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..320		16/56 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6194
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	1	1.000	-	-		otm40488
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45771
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.910