DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and HOXA3

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	353	Identity:	93/353 - (26%)
Similarity:	138/353 - (39%)	Gaps:	87/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 ANGYYGGYGGGYGTANGSVGSTHSQ----------------------------GHSPHSQMMDLP 243
            ::..||||  .|..|||...:.:.|                            ||....::.:..
Human     9 SSAIYGGY--PYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEAC 71

  Fly   244 LQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLD 308
            |:..|..|....:||..    .|.....:|.|...|..:...:.......:.....|
Human    72 LRTLSAPPSQPPSLGEP----PLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSS-------- 124

  Fly   309 RSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMK------KIHVAGVANG------SYQ 361
            .||.:..||:..    .:::.:..:..:....:.|:||||      |...:..::|      ...
Human   125 ASPPQNASNNPT----PANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSP 185

  Fly   362 PGM-EPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDN 425
            ||. ..||.|||||..|::|||||||:||||.|.||:|:|:.|.|:||||||||||||||:|||.
Human   186 PGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 250

  Fly   426 KLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLE 490
            |       .|..:.::|..:| ::.|....|............|...:.|..|..::
Human   251 K-------GKGMLTSSGGQSP-SRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSK-------- 299

  Fly   491 SIGDVSSSLGNPPYIPAAPETTSSYPGS 518
               ....:.|.||         :|||.|
Human   300 ---PPQGTYGLPP---------ASYPAS 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	38/51 (75%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		13/87 (15%)
		Antp-type hexapeptide	155..160		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		8/36 (22%)
		Homeobox	195..248	CDD:395001	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		19/97 (20%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810