DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dfd and HOXA2

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens

Alignment Length:	240	Identity:	72/240 - (30%)
Similarity:	97/240 - (40%)	Gaps:	68/240 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 YPWMKKIHVA-----------------------------GVANGSYQPGMEPKRQRTAYTRHQIL 379
            |||||:...|                             .:|:||   |...:|.|||||..|:|
Human    95 YPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGS---GGGSRRLRTAYTNTQLL 156

  Fly   380 ELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGN- 443
            |||||||:|:||.|.||:|||..|.|:|||:|:||||||||.|:..:....:|...|......:
Human   157 ELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSE 221

  Fly   444 --------------PTPVAKKPTKRAASKKQQQAQQQQQS---QQQQTQQTPVMNECIRSDSLES 491
                          ...|:....:|.....||.|..|||:   ....:|..||........:|:.
Human   222 KVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKH 286

  Fly   492 IGDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNN 536
            ....|         |..|...|:.         ..|.|:|.||::
Human   287 FQHQS---------PTVPNCLSTM---------GQNCGAGLNNDS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	37/51 (73%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93
		Antp-type hexapeptide	94..99		3/3 (100%)
		Homeobox	147..200	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279		6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810