DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and hoxd3a

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	368	Identity:	101/368 - (27%)
Similarity:	144/368 - (39%)	Gaps:	104/368 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 GYYGGYGGGYGTANG-SVGSTHSQGHSPHS-----QMMDLPLQCSSTEPPTNTALGLQELGLKLE 267
            |.:|||  .|..::. :.|.|| ||.|..|     |....|:|.:|
Zfish    11 GLFGGY--SYPKSDSYTYGPTH-QGFSSSSIENDYQSPICPIQTTS------------------- 53

  Fly   268 KRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRL--MLDRSPDELGSNDNDDDLGDSDSDE 330
              :.:|......:....||.......|:.:.:||:.:.  :...||   ..:.|......|.|..
Zfish    54 --VRQATHKNGDINGSCMRPSASQGNSQPESISEQQQAAPLAASSP---SPSTNSTQKKKSPSSN 113

  Fly   331 DLMAETTDGERIIYPWMKKIH-----------VAG-VANGSYQPGMEPKRQRTAYTRHQILELEK 383
            .....|....:.|:||||:..           .|| ..:....||...||.|||||..|::||||
Zfish   114 GSSTATPVISKQIFPWMKETRQNAKQKSTNCPAAGETCDDKSPPGPASKRVRTAYTSAQLVELEK 178

  Fly   384 EFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVA 448
            |||:||||.|.||:|:|:.|.|:||||||||||||||:|||.|   :|.:..         :|:.
Zfish   179 EFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQK---SKGIMH---------SPLG 231

  Fly   449 KKPTKRAASKKQQQAQQQQQSQQQQTQQTPVM---NECIRSDSLESIGDVSSSLGNPPYIPAAPE 510
            ..|                       .::|.:   |....|..|.::..:|....:||.. |.|:
Zfish   232 HSP-----------------------DRSPPLSGSNHIGYSGQLPNVNSLSYDAPSPPSF-AKPQ 272

  Fly   511 TT------------------SSYPGSQQHLSNNNNNGSGNNNN 535
            ..                  ..|||::....:...|||..|.|
Zfish   273 QNIYGLAAYTAPLGGCIPQQKRYPGTEYDHHSMQGNGSFANAN 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	38/51 (75%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		33/169 (20%)
		Abdominal-A	116..237	CDD:332641	57/155 (37%)
		Antp-type hexapeptide	126..131		3/4 (75%)
		Homeobox	165..217	CDD:306543	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		7/61 (11%)
		DUF4074	333..394	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4567
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860