DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and hoxb4a

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_571193.1	Gene:	hoxb4a / 30340	ZFINID:	ZDB-GENE-990415-105	Length:	246	Species:	Danio rerio

Alignment Length:	342	Identity:	109/342 - (31%)
Similarity:	139/342 - (40%)	Gaps:	123/342 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SSNYANAT-PPSHPHSHPHAHPHQSLGYYVHHAPEFISAGAVHSDPT-------NGYGPAANVPN 184
            :|||.:.. ||...:|       || .|...|:|::.|  |...||:       :.....|:.|.
Zfish     9 NSNYVDPKFPPCEEYS-------QS-DYLPSHSPDYYS--AQRQDPSFQHESIYHQRSGCADPPY 63

  Fly   185 TSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDLPL----- 244
            :|..|.|..:..:                               ..:||...:..:..||
Zfish    64 SSCQGPGQPAAVI-------------------------------SPRGHVLPTTALSTPLPEPSH 97

  Fly   245 QCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDR 309
            .|.|..|....|.|              ..|..|....:..|                      :
Zfish    98 HCDSVTPSPPPACG--------------QTPTSQNTSTVSSR----------------------K 126

  Fly   310 SPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYT 374
            .|                              ::||||||:|| .:.:.:|..| ||||.|||||
Zfish   127 DP------------------------------VVYPWMKKVHV-NIVSPNYSGG-EPKRSRTAYT 159

  Fly   375 RHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVD 439
            |.|:||||||||||||||||||:||||||.||||||||||||||||||||:|||||| :|..:..
Zfish   160 RQQVLELEKEFHYNRYLTRRRRVEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTK-IRSNSAS 223

  Fly   440 ANGNPTPVAKKPTKRAA 456
            .|.:..|.......||:
Zfish   224 TNSSGCPTLCSNQSRAS 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	47/51 (92%)
hoxb4a	NP_571193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..125		26/156 (17%)
		Antp-type hexapeptide	130..135		3/4 (75%)
		Homeobox	154..207	CDD:278475	47/52 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..246		11/32 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6027
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	1	1.000	-	-		otm26182
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45771
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4536
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.940