DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and hoxb2a

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_571191.1	Gene:	hoxb2a / 30338	ZFINID:	ZDB-GENE-990415-103	Length:	390	Species:	Danio rerio

Alignment Length:	234	Identity:	69/234 - (29%)
Similarity:	98/234 - (41%)	Gaps:	79/234 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 YPWMKK------------IHVAGVANGS----------------YQPGME----PKRQRTAYTRH 376
            :||||:            ...|..|:.|                .|.|::    .:|.|||||..
Zfish   104 FPWMKEKKSSKKCPKPGATAAAAAASPSQASSGYTTAGLESPTEIQGGLDNVSGSRRLRTAYTNT 168

  Fly   377 QILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKK------------------ 423
            |:||||||||:|:||.|.||:|||..|.|:|||:|:||||||||.|:
Zfish   169 QLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTTHHRDGQEGEPSGFDL 233

  Fly   424 ----DNKLPNTKNVRKKTVDANGNPTPVAKK--PTKRA---ASKKQQQAQQQQQSQQQQTQQTPV 479
                |...|.:.  :...|..:|:..|...:  ||..|   :|.|.|...::.|:.|.:....|
Zfish   234 LEGTDASSPYSS--QSLEVSGSGSAAPSESETCPTTAAYTNSSDKSQPTPEEGQASQPEPASVP- 295

  Fly   480 MNECIRSDSLESIGDVSSSLGNPPY-IPAAPETTSSYPG 517
                            .:::.:||| .|.|...|:...|
Zfish   296 ----------------DTAVHSPPYPTPTADNPTTMAEG 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	37/51 (73%)
hoxb2a	NP_571191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Antp-type hexapeptide	103..108		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..155		6/46 (13%)
		Homeobox	162..214	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..338		24/127 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900