Protein Alignment Dfd and EN2

DIOPT Version :9

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001418.2
• Gene: EN2 / 2020
• HGNCID: 3343
• Length: 333
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 100/382 - (26%)
• Similarity: 139/382 - (36%)
• Gaps: 112/382 - (29%)

  Fly   114 SAISGHHQ--ASAGGYSSNYANATP-------------------PSHPHSHPHAHPHQSLGYYVH 157
            :|:.|..|  :|.||.|.....::|                   |.:     |.|||:...:::.
Human    13 AAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGN-----HQHPHRITNFFID 72

  Fly   158 H--APEFISAGAVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGT 220
            :  .|||              |...:......|.|||..|   |.|..||::....||..||...
Human    73 NILRPEF--------------GRRKDAGTCCAGAGGGRGG---GAGGEGGASGAEGGGGAGGSEQ 120

  Fly   221 ANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGM 285
            ..|| ||...:.:.|.:.....||..:.::.|.:...|.:.|.|.                  |.
Human   121 LLGS-GSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLH------------------GG 166

  Fly   286 RLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYP-WM-- 347
            ..:..|.|..           ||.|....|....|..: .||||..........:.:::| |:
Human   167 AKKGGDPGGP-----------LDGSLKARGLGGGDLSV-SSDSDSSQAGANLGAQPMLWPAWVYC 219

  Fly   348 -----------------KKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRR 395
                             ||           .|..|.||.|||:|..|:..|:.||..|||||.:|
Human   220 TRYSDRPSSGPRSRKPKKK-----------NPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQR 273

  Fly   396 RIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANG--NPTPVAKK 450
            |..:|..|.|:|.||||||||:|.|.||.....||..|.   :.|.|  |.:..||:
Human   274 RQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVH---LMAQGLYNHSTTAKE 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	29/51 (57%)
EN2	NP_001418.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..206		33/144 (23%)
		homeobox domain	243..302		33/58 (57%)
		Homeobox	247..300	CDD:306543	29/52 (56%)
		Engrail_1_C_sig	302..331	CDD:313702	8/29 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910