DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and Pax6

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001231127.1	Gene:	Pax6 / 18508	MGIID:	97490	Length:	436	Species:	Mus musculus

Alignment Length:	259	Identity:	64/259 - (24%)
Similarity:	91/259 - (35%)	Gaps:	88/259 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 GSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQRTAYTRHQIL 379
            |.|.|.......||||                         |....|...:.:|.||::|:.||.
Mouse   198 GENTNSISSNGEDSDE-------------------------AQMRLQLKRKLQRNRTSFTQEQIE 237

  Fly   380 ELEKEF---HYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDAN 441
            .|||||   ||.....|.|   :|..:.|.|.:|::||.|||.||:::.||.|.:.      .|:
Mouse   238 ALEKEFERTHYPDVFARER---LAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRR------QAS 293

  Fly   442 GNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIGDVSSSL------- 499
            ..|:.:   |...:.|....|...|        ..|||.:  ..|.|:  :|...::|
Mouse   294 NTPSHI---PISSSFSTSVYQPIPQ--------PTTPVSS--FTSGSM--LGRTDTALTNTYSAL 343

  Fly   500 ---------GNPPYIPAAPETTSSY--------------------PGSQQHLSNNNNNGSGNNN 534
                     .|.|..|..|..||||                    |..|.|:::.....||..:
Mouse   344 PPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTS 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	24/54 (44%)
Pax6	NP_001231127.1	PAX	4..142	CDD:128645
Pax6	NP_001231127.1	Homeobox	228..281	CDD:395001	25/55 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910